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業績集 消化管外科学講座 令和3年(2021年)

(分類は大学の業績集に準じています)

(1) 論文

①原著 (筆頭著者のイニシアル順)
1. Gonda K, Horita S, Maejima Y, Takenoshita S, Shimomura K. Soluble interleukin-2 Receptor as a Predictive and Prognostic Marker for Patients with Familial Breast Cancer. Sci Prog. 104(3):1-15, 2021.
2. Gonda K, Kanazawa H, Maeda G, Matayoshi C, Hirose N, Katsumoto Y, Kono K, Takenoshita S. Ingestion of Okinawa Island Vegetables Increases IgA Levels and Prevents the Spread of Influenza RNA Viruses. Nutrients. 13(6):1773, 2021.
3. Gonda K, Suzuki K, Sunabe Y, Kono K, Takenoshita S. Ficus Pumila L. Improves the Prognosis of Patients Infected with HTLV-1, an RNA virus. Nutr J. 20(1):16, 2021.
4. Hori S, Honda M, Kobayashi H, Kawamura H, Takiguchi K, Muto A, Yamazaki S, Teranishi Y, Shiraso S, Kono K, Kamiga T, Iwao T, Yamashita N. A Grading System for Predicting the Prognosis of Gastric Cancer with Liver Metastasis. Jpn J Clin Oncol. 51(11):1601-1607, 2021.
5. Kase K, Saito M, Nakajima S, Takayanagi D, Saito K, Yamada L, Ashizawa M, Nakano H, Hanayama H, Onozawa H, Okayama H, Endo H, Fujita S, Sakamoto W, Saze Z, Momma T, Mimura K, Ohki S, Shiraishi K, Kohno T, Kono K. ARID1A Deficiency in EBV-positive Gastric Cancer is Partially Regulated by EBV-encoded miRNAs, but not by DNA Promotor Hypermethylation. Carcinogenesis. 42(1):21-30, 2021.
6. Kawamura H, Ogawa Y, Yamazaki H, Honda M, Kono K, Konno S, Fukuhara S, Yamamoto Y. Impact of Primary Tumor Resection on Mortality in Patients with Stage IV Colorectal Cancer with Unresectable Metastases: A Multicenter Retrospective Cohort Study. World J Surg. 45(10):3230-3239, 2021.
7. Kawamura H, Honda M, Takiguchi K, Kamiga T, Saito K, Muto A, Shiraso S, Yamashita N, Iwao T, Saji S, Kono K, Konno S. Clinical Impact of Primary Tumor Site in Stage IV Colorectal Cancer: A Statewide Cohort Study. Anticancer Res. 41(11):5693-5702, 2021.
8. Kubo Y, Kitagawa Y, Miyazaki T, Sohda M, Yamaji T, Sakai M, Saeki H, Nemoto K, Oyama T, Muto M, Takeuchi H, Toh Y, Matsubara H, Mano M, Kono K, Kato K, Yoshida M, Kawakubo H, Booka E, Yamatsuji T, Kato H, Ito Y, Ishikawa H, Ishihara R, Tsushima T, Kawachi H, Oyama T, Kojima T, Kuribayashi S, Makino T, Matsuda S, Doki Y. Esophageal Cancer Practice Guidelines Preparation Committee. The Potential for Reducing Alcohol Consumption to Prevent Esophageal Cancer Morbidity in Asian Heavy Drinkers: A Systematic Review and Meta-analysis. Esophagus. Online ahead of print. 2021.
9. Kobayashi Y, Kumamoto K, Okayama H, Matsumoto T, Nakano H, Saito K, Matsumoto Y, Endo E, Kanke Y, Watanabe Y, Onozawa H, Fujita S, Sakamoto W, Saito M, Momma T, Takenoshita S, Kono K. Downregulation of PAICS due to loss of Chromosome 4q is Associated with Poor Survival in Stage III Colorectal Cancer. PLoS One. 16(2):e0247169, 2021.
10. Mimura K, Kua LF, Xiao JF, Asuncion BR, Nakayama Y, Syn N, Fazreen Z, Soong R, Kono K, Yong WP. Combined inhibition of PD-1/PD-L1, Lag-3, and Tim-3 Axes Augments Antitumor Immunity in Gastric Cancer-T Cell Coculture Models. Gastric Cancer. 24(3):611-623, 2021.
11. Min AKT, Mimura K, Nakajima S, Okayama H, Saito K, Sakamoto W, Fujita S, Endo H, Saito M, Saze Z, Momma T, Ohki S, Kono K. Therapeutic Potential of anti-VEGF Receptor 2 Therapy Targeting for M2-tumor-associated Macrophages in Colorectal Cancer. Cancer Immunol Immunother. 70(2):289-298, 2021.
12. Miyanaga A, Matsumoto M, Beck JA, Horikawa I, Oike T, Okayama H, Tanaka H, Burkett SS, Robles AI, Khan M, Lissa D, Seike M, Gemma A, Mano H, Harris CC. EML4-ALK Induces Cellular Senescence in Mortal Normal Human Cells and Promotes Anchorage-independent Growth in hTERT-transduced Normal Human Cells. BMC Cancer. 21(1):310, 2021.
13. Momma T, Okayama H, Kanke Y, Fukai S, Onozawa H, Fujita S, Sakamoto W, Saito M, Ohki S, Kono K. Validation of Gene Expression-Based Predictive Biomarkers for Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer. Cancers (Basel). 13(18):4642, 2021.
14. Matsumoto T, Okayama H, Nakajima S, Saito K, Ito M, Kaneta A, Kanke Y, Onozawa H, Hayase S, Fujita S, Sakamoto W, Saito M, Seze Z, Momma T, Mimura K, Kono K. SH2D4A Downregulation due to Loss of Chromosome 8p is Associated with Poor Prognosis and Low T Cell Infiltration in Colorectal Cancer. Br J Cancer. Online ahead of print. 2021.
15. Nakajima S, Mimura K, Matsumoto T, Thar Min AK, Ito M, Nakano H, Neupane P, Kanke Y, Okayama H, Saito M, Momma T, Watanabe Y, Hanayama H, Hayase S, Saze Z, Kono K. The Effects of T-DXd on the Expression of HLA Class I and Chemokines CXCL9/10/11 in HER2-Overexpressing Gastric Cancer Cells. Sci Rep. 11(1):16891, 2021.
16. Nakajima S, Mimura K, Saito K, Thar Min AK, Endo E, Yamada L, Kase K, Yamauchi N, Matsumoto T, Nakano H, Kanke Y, Okayama H, Saito M, Neupane P, Saze Z, Watanabe Y, Hanayama H, Hayase S, Kaneta A, Momma T, Ohki S, Ohira H, Kono K. Neoadjuvant Chemotherapy Induces IL34 Signaling and Promotes Chemoresistance via Tumor-Associated Macrophage Polarization in Esophageal Squamous Cell Carcinoma. Mol Cancer Res. 19(6):1085-1095, 2021.
17. Nakano H, Saito M, Nakajima S, Saito K, Nakayama Y, Kase K, Yamada L, Kanke Y, Hanayama H, Onozawa H, Okayama H, Fujita S, Sakamoto W, Saze Z, Momma T, Mimura K, Ohki S, Goto A, Kono K. PD-L1 Overexpression in EBV-positive Gastric Cancer is Caused by Unique Genomic or Epigenomic Mechanisms. Sci Rep. 11(1):1982, 2021.
18. Nakayama Y, Kawamura H, Honda M, Takano Y, Takiguchi K, Kamiga T, Yamazaki S, Muto A, Shiraso S, Yamashita N, Iwao T, Kono K, Konno S. Benefit of Intensive Chemotherapy for Elderly Patients Aged 80 Years or Older with Metastatic Colorectal Cancer: A State-Wide Multicenter Cohort Study. Int J Clin Oncol. 26(7):1248-1256, 2021.
19. Neupane P, Mimura K, Nakajima S, Okayama H, Ito M, Thar Min AK, Saito K, Onozawa H, Fujita S, Sakamoto W, Saito M, Saze Z, Momma T, Kono K. The Expression of Immune Checkpoint Receptors and Ligands in the Colorectal Cancer Tumor Microenvironment. Anticancer Res. 41(10):4895-4905, 2021.
20. Neupane P, Bhandari D, Tsubokura M, Shimazu Y, Zhao T, Kono K. The Nepalese Health Care System and Challenges During COVID-19. J Glob Health. 11:03030, 2021.
21. Petersen SH, Kua LF, Nakajima S, Yong WP, Kono K. Chemoradiation induces Upregulation of Immunogenic Cell Death-related Molecules Together with Increased Expression of PD-L1 and Galectin-9 in Gastric Cancer. Sci Rep. 11(1):12264, 2021.
22. Sakai M, Kitagawa Y, Saeki H, Miyazaki T, Yamaji T, Nemoto K, Oyama T, Muto M, Takeuchi H, Toh Y, Matsubara H, Mano M, Kono K, Kato K, Yoshida M, Kawakubo H, Booka E, Yamatsuji T, Kato H, Ito Y, Ishikawa H, Ishihara R, Tsushima T, Kawachi H, Oyama T, Kojima T, Kuribayashi S, Makino T, Matsuda S, Sohda M, Kubo Y, Doki Y. Esophageal Cancer Practice Guidelines Preparation Committee. Fruit and Vegetable Consumption and Risk of Esophageal Cancer in the Asian Region: A Systematic Review and Meta-analysis. Esophagus. Online ahead of print. 2021.
23. Sakamoto W, Ohki S, Onozawa H, Okayama H, Endo H, Fujita S, Saito M, Saze Z, Momma T, Takenoshita S, Kono K. Long-term Outcomes of Lower Rectal Cancer Patients Treated with Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection after Preoperative Radiotherapy or Chemoradiotherapy. J Anus Rectum Colon. 5(2):129-136, 2021.
24. Saze Z, Kase K, Nakano H, Yamauchi N, Kaneta A, Watanabe Y, Hanayama H, Hayase S, Momma T, Kono K. Functional Benefits of the Double Flap Technique After Proximal Gastrectomy for Gastric Cancer. BMC Surg. 21(1):392, 2021.
25. Shibata M, Kono K, Takenoshita S. Inhibiting VEGF in Cancer Immunotherapy. Clinical Immunology Communications. 2:12-16, 2022.
26. Suzuki K, Gonda K, Kishimoto Y, Katsumoto Y, Takenoshita S. Potential Curing and Beneficial Effects of Ooitabi (Ficus pumila L.) on Hypertension and Dyslipidaemia in Okinawa. J Hum Nutr Diet. 34(2):395-401, 2021.
27. Takao M, Yamaguchi T, Eguchi H, Yamada T, Okazaki Y, Tomita N, Nomizu T, Momma T, Takayama T, Tanakaya K, Akagi K, Ishida H. APC Germline Variant Analysis in the Adenomatous Polyposis Phenotype in Japanese Patients. Int J Clin Oncol. 26(9):1661-1670. 2021.
28. Takeshita E, Ishibashi K, Koda K, Oda N, Yoshimatsu K, Sato Y, Oya M, Yamaguchi S, Nakajima H, Momma T, Maekawa H, Tsubaki M, Yamada T, Kobayashi M, Tanakaya K, Ishida H. The Updated Five‑year Overall Survival and Long‑term Oxaliplatin‑related Neurotoxicity Assessment of the FACOS Study. Surg Today. 51(8):1309-1319, 2021.
29. Ujiie D, Matsumoto T, Endo E, Okayama H, Fujita S, Kanke Y, Watanabe Y, Hanayama H, Hayase S, Saze Z, Ohki S, Kono K. Circulating Tumor Cells After Neoadjuvant Chemotherapy are Related with Recurrence in Esophageal Squamous Cell Carcinoma. Esophagus. 18(3):566-573, 2021.
30. Watanabe M, Toh Y, Ishihara R, Kono K, Matsubara H, Murakami K, Muro K, Numasaki H, Oyama T, Ozawa S, Saeki H, Tanaka K, Tsushima T, Ueno M, Uno T, Yoshio T, Usune S, Takahashi A, Miyata H. Registration Committee for Esophageal Cancer of the Japan Esophageal Society. Comprehensive Registry of Esophageal Cancer in Japan, 2014. Esophagus. Online ahead of print. 2021.
31. Watanabe M, Tachimori Y, Oyama T, Toh Y, Matsubara H, Ueno M, Kono K, Uno T, Ishihara R, Muro K, Numasaki H, Tanaka K, Ozawa S, Murakami K, Usune S, Takahashi A, Miyata H. Registration Committee for Esophageal Cancer of the Japan Esophageal Society. Comprehensive Registry of Esophageal Cancer in Japan, 2013. Esophagus. 18(1):1-24, 2021.
32. Yamada L, Saito M, Thar Min AK, Saito K, Ashizawa M, Kase K, Nakajima S, Onozawa H, Okayama H, Endo H, Fujita S, Sakamoto W, Saze Z, Momma T, Mimura K, Ohki S, Kono K. Selective Sensitivity of EZH2 Inhibitors Based on Synthetic Lethality in ARID1A-Deficient Gastric Cancer. Gastric Cancer. 24(1):60-71, 2021.
33. Yamamoto R, Honda M, Kawamura H, Kobayashi H, Takiguchi K, Muto A, Yamazaki S, Teranishi Y, Shiraso S, Kono K, Hori S, Kamiga T, Iwao T, Yamashita N. Clinical Features and Survival of Young Adults with Stage IV Gastric Cancer: a Japanese Population-Based Study. J Gastrointest Cancer. Online ahead of print. 2021.
34. Yamauchi N, Kanke Y, Saito K, Okayama H, Yamada S, Nakajima S, Endo E, Kase K, Yamada L, Nakano H, Matsumoto T, Hanayama H, Watanabe Y, Hayase S, Saito M, Saze Z, Mimura K, Momma T, Oki S, Hashimoto Y, Kono K. Stromal Expression of Cancer-associated Fibroblast-Related Molecules, Versican and Lumican, is Strongly Associated with Worse Relapse-free and Overall Survival Times in Patients with Esophageal Squamous Cell Carcinoma. Oncol Lett. Jun;21(6):445, 2021.
35. Yang HK, Ji J, Han SU, Terashima M, Li G, Kim HH, Law S, Shabbir A, Song KY, Hyung WJ, Kosai NR, Kono K, Misawa K, Yabusaki H, Kinoshita T, Lau PC, Kim YW, Rao JR, Ng E, Yamada T, Yoshida K, Park DJ, Tai BC, So JBY. EXPEL Study Group. Extensive Peritoneal Lavage with Saline After Curative Gastrectomy for Gastric Cancer (EXPEL): A Multicentre Randomised Controlled Trial. Lancet Gastroenterol Hepatol. 6(2):120-127, 2021.
36. 大木進司, 岡山洋和, 千田峻, 坂本渉, 藤田正太郎, 齋藤元伸, 門馬智之, 佐瀬善一郎, 河野浩二.
High risk stage Ⅱ大腸癌におけるGlasgow prognostic scoreの意義と治療戦略. 癌と化学療法. 48(13):1770-1773, 2021.
②総説等
1. Saito M, Kono K. Landscape of EBV-Positive Gastric Cancer. Gastric Cancer. 24(5):983-989, 2021.
2. Ujiie D, Okayama H, Kono K. The Role of KRT17 in Colorectal Cancer. Aging (Albany NY) 13(16):19950-19951, 2021.
3. 河野浩二. 複合的免疫療法 放射線照射とがん免疫療法の併用療法. 臨床外科. 73(3):356-361, 2021.
4. 河野浩二. 胃癌の免疫療法. 医学と薬学. 78(10);1183-1190, 2021.
5. 河野浩二, 藤原俊義. 新型コロナウイルス感染症(COVID-19)パンデミック時の食道癌手術で気をつけることは? ICUの機能低下や、人工呼吸器不足、医療チームのマンパワーなどを慎重に判断して、食道癌の手術療法を実施する必要がある. 日本医事新報 5046:50-51, 2021.
6. 三村耕作, 菊池智宏, 河野浩二. 大腸癌腫瘍微小環境における腸内細菌と腫瘍浸潤免疫担当細胞の関連について. 癌と化学療法. 48(9):1093-1095, 2021.
7. 松本拓朗, 岡山洋和, 仲野宏, 伊藤美郷, 中嶋正太郎, 齋藤元伸, 佐瀬善一郎, 門馬智之, 三村耕作, 河野浩二. ミスマッチ修復機構欠損大腸癌における糖鎖抗原を標的とした免疫療法の可能性. 癌と化学療法. 48(10):1275-1277, 2021.
8. 木村隆, 横山斉, 鈴木眞一, 河野浩二, 丸橋繁, 鈴木弘行, 大竹徹, 田中秀明. GeneralityとSpecialtyのバランスのとれた外科医の育成を目指して―なんでもできる外科医の魅力をもう一度―. 日本外科学会雑誌. 122(1):90-92, 2021.
9. 鳫翔大郎, 巌康仁, 佐藤公太, 千代延記道, 坂井義博, 丸山裕也, 杉本桃子, 深井智司, 赤繁徹, 遠藤久仁, 伊藤泰輔, 山田睦夫, 石井芳正, 今村秀道, 山崎繁. COVID-19パンデミックによる当院での急性胆嚢炎診療への影響. 太田綜合病院学術年報. 56:11-18, 2021.
10. 鳫翔大郎, 巌康仁, 佐藤公太, 千代延記道, 坂井義博, 丸山裕也, 杉本桃子, 深井智司, 赤繁徹, 遠藤久仁, 伊藤泰輔, 山田睦夫, 石井芳正, 山崎繁. 「《緊急特別企画》パンデミック状況下における外科診療と教育」COVID-19パンデミックによる急性胆嚢炎診療への影響. 日本外科学会雑誌. 122(5):561-564, 2021.
③症例報告
1. Kanazawa H, Gonda K, Tamura T, Takenoshita S. A Case of Lipoma, Calcification, and Brain Malformations in the Midline of the Skull. Radiol Case Rep. 16(9):2509-2513, 2021.
2. Miyabe K, Saito M, Koyama K, Umakoshi M, Ito Y, Yoshida M, Kudo‑Asabe Y, Saito K, Nanjo H, Maeda D, Matsusaka K, Goto A, Kono K. Collision of Epstein-Barr Virus‑positive and ‑negative Gastric Cancer, Diagnosed by Molecular Analysis. BMC Gastroenterol. 21:97, 2021.
3. Yanagita T, Hikichi T, Nakamura J, Watanabe K, Kikuchi H, Takasumi M, Hashimoto M, Kato T, Kobashi R, Takagi T, Suzuki R, Sugimoto M, Sato Y, Irie H, Hanayama H, Saze Z, Kobayakawa M, Kono K, Ohira H. Gastric Carcinoma with Lymphoid Stroma Diagnosed by Endoscopic Ultrasound‑guided Fine‑needle Aspiration. Clin J Gastroenterol. 14(2):471-477, 2021.
4. 小野澤寿志, 山田玲央, 菅家康之, 藤田正太郎, 坂本渉, 門馬智之. 敗血症とDICを合併した非穿孔性急性虫垂炎の1例. 日本大腸肛門病学会雑誌. 74(6):364-368, 2021.
5. 望月翔太朗, 山田玲央, 加瀬晃志, 伊藤美郷, 仲野宏, 山内直人, 松本拓朗, 金田晃尚, 菅家康之, 中島隆宏, 花山寛之, 渡辺洋平, 小野澤寿志, 早瀬傑, 岡山洋和, 藤田正太郎, 坂本渉, 齋藤元伸, 門馬智之, 佐瀬善一郎, 三村耕作, 大木進司, 河野浩二. 術前確定診断された肺癌胃転移に対して腹腔鏡下切除術を施行した1 例. 癌と化学療法. 48(9):1093-1095, 2021.
6. 小島つかさ, 小山善久, 伊藤美郷, 早瀬傑, 齋藤勝, 阿美弘文, 内海康文, 川名聡. がん検診で発見されたSolid-pseudopapillary neoplasmの一例. 大原記念財団年報. 57:37-43, 2021.
7. 竹村真生子, 岡崎護, 羽成直行, 徳田恵美, 田辺真彦, 林嗣博, 水谷知央, 林孝朗, 中村優飛, 根本悠里, 佐久間芽衣, 叶多諒, 萩尾浩太郎, 絹田俊爾, 山口佳子, 輿石直樹. Everolimus+Exemestane療法後に腫瘍崩壊症候群をきたした進行乳癌の一例. 福島医学雑誌. 71(1):35-40,2021.
8. 仲野宏, 渡辺洋平, 伊藤美郷, 加瀬晃志, 山内直人, 松本拓朗, 金田晃尚, 花山寛之, 早瀬傑, 門馬智之, 佐瀬善一郎, 三村耕作, 河野浩二.  正中弓状靱帯圧迫症候群に伴う胃十二指腸動脈瘤により出血性十二指腸潰瘍をきたした1例. 日本腹部救急医学会雑誌 41(6):449-452, 2021.
9. 角田圭一, 青砥慶太, 大須賀文彦, 田崎和洋, 遠藤豪一. Rhabdoid featureを呈し急速に進行した横行結腸癌の1例. 日本臨床外科学会雑誌 82(7):1376-1380, 2021.
10. 白岩彩, 古川茂宜, 藤森実杜, 福田冬馬, 植田牧子, 遠藤雄大, 小島学, 小野澤寿志, 坂本渉, 添田周, 渡邉尚文, 鈴木博志, 藤森敬也. 卵巣腫瘍茎捻転との鑑別を要し、腹腔鏡下に整復し得た子宮広間膜ヘルニアの一例. 福島医学雑誌 71(1):41-45, 2021.

(2) 知的財産権

1. 発明者:岡山洋和、野田勝、河野浩二.特許第6833226号. 発明の名称:大腸がんの予後バイオマーカー. 登録日 令和3年2月5日.

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