~統合再編から世界に向けて~

福島県立医科大学 消化管外科学講座

業績

ホーム > 業績

業績集 消化管外科学講座 令和元年(2020年)

(分類は大学の業績集に準じています)

(1) 論文

①原著 (筆頭著者のイニシアル順)
1. Min AKT, Mimura K, Nakajima S, Okayama H, Saito K, Sakamoto W, Fujita S, Endo H, Saito M, Saze Z, Momma T, Ohki S, Kono K. Therapeutic potential of anti-VEGF receptor 2 therapy targeting for M2-tumor-associated macrophages in colorectal cancer. Cancer Immunol Immunother. 2020.
2. Patel DP, Pauly GT, Tada T, Parker AL, Toulabi L, Kanke Y, Oike T, Krausz KW, Gonzalez FJ, Harris CC. Improved detection and precise relative quantification of the urinary cancer metabolite biomarkers – Creatine riboside, creatinine riboside, creatine and creatinine by UPLC-ESI-MS/MS: Application to the NCI-Maryland cohort population controls and lung cancer cases. J Pharm Biomed Anal. 191:113596, 2020.
3. Endo E, Okayama H, Saito K, Nakajima S, Yamada L, Ujiie D, Kase K, Fujita S, Endo H, Sakamoto W, Saito M, Saze Z, Momma T, Ohki S, Mimura K, Kono K. A TGFβ-Dependent Stromal Subset Underlies Immune Checkpoint Inhibitor Efficacy in DNA Mismatch Repair-Deficient/Microsatellite Instability-High Colorectal Cancer. Mol Cancer Res. 18(9):1402-1413, 2020.
4. Yang HK, Ji J, Han SU, Terashima M, Li G, Kim HH, Law S, Shabbir A, Song KY, Hyung WJ, Kosai NR, Kono K, Misawa K, Yabusaki H, Kinoshita T, Lau PC, Kim YW, Rao JR, Ng E, Yamada T, Yoshida K, Park DJ, Tai BC, So JBY; EXPEL study group. Extensive peritoneal lavage with saline after curative gastrectomy for gastric cancer (EXPEL): a multicentre randomised controlled trial. Lancet Gastroenterol Hepatol. 6(2): 120-127, 2021.
5. Honda M, Kawamura H, Kobayashi H, Takiguchi K. Muto A, Yamazaki S, Teranishi Y, Shiraso S, Kono K, Hori S, KamigaT, Iwao T, Yamashita N. An ascites grading system for predicting the prognosis of gastric cancer with peritoneum dissemination. Ann Gastroenterol Surg. 4(6):660–666, 2020.
6. Ito T, Kono K, Eguchi H, Okazaki Y, Yamamoto G, Tachikawa T, Akagi K, Okada Y, Kawakami S, Morozumi M, Tamaru J, Ishida H. Prevalence of Lynch syndrome among patients with upper urinary tract carcinoma in a Japanese hospital-based population. Jpn J Clin Oncol. 50(1):80-88, 2020.
7. Kase K, Saito M, Nakajima N, Takayanagi D, Saito K, Yamada L, Ashizawa M, Nakano H, Hanayama H, Onozawa H, Okayama H, Endo H, Fujita S, Sakamoto W, Saze Z, Momma T, Mimura K, Ohki S, Shiraishi K, Kohno T, Kono K. ARID1A deficiency in EBV-positive gastric cancer is partially regulated by EBV-encoded miRNAs, but not by DNA promotor hypermethylation. Carcinogenesis. 2020.
8. Kikuchi T, Mimura K, Ashizawa M, Okayama H, Endo E, Saito K, Sakamoto W, Fujita S, Endo H, Saito M, Momma T, Saze Z, Ohki S, Shimada K, Yoshimura K, Tsunoda T, Kono K. Characterization of tumor-infiltrating immune cells in relation to microbiota in colorectal cancers. Cancer Immunol Immunother. 69(1):23-32, 2020.
9. Matsumoto T, Okayama H, Nakajima S, Saito K, Nakano H, Endo E, Kase K, Ito M, Yamauchi N, Yamada L, Kanke Y, Onozawa H, Fujita S, Sakamoto S, Saito M, Saze Z, Momma T, Mimura K, Kono K. Tn Antigen Expression Defines an Immune Cold Subset of Mismatch-Repair Deficient Colorectal Cancer. Int J Mol Sci. 21(23):9081, 2020.
10. Mimura K, Kua LF, Xiao JF, Asuncion BR, Nakayama Y, Syn N, Fazreen Z, Soong R, Kono K, Yong WP. Combined inhibition of PD-1/PD-L1, Lag-3, and Tim-3 axes augments antitumor immunity in gastric cancer-T-cell coculture models. Gastric Cancer. 2020.
11. Nakajima S, Manita S, Yu G, Ishimaru K, Kono K, Kitamura K, Nakao A. Activation of the reward system ameliorates passive cutaneous anaphylactic reaction in mice. Allergy. 75(12):3275-3279, 2020.
12. Nakayama Y, Mimura K, Kua LF, Okayama H, Min AKT, Saito K, Hanayama H, Watanabe Y, Saito M, Momma T, Saze Z, Ohki S, Suzuki S, Ichikawa D, Yong WP, Kono K. Immune suppression caused by PD-L2 expression on tumor cells in gastric cancer. Gastric Cancer. 23(6):961-973, 2020.
13. Okano M, Oshi M, Butash A, Okano I, Saito K, Kawaguchi T, Nagahashi M, Kono K, Ohtake T, Takabe K. Orthotopic Implantation Achieves Better Engraftment and Faster Growth Than Subcutaneous Implantation in Breast Cancer Patient-Derived Xenografts. J Mammary Gland Biol Neoplasia. 25(1):27-36, 2020
14. Oshi M, Okano M, Maiti A, Rashid OM, Saito K, Kono K, Matsuyama R, Endo I, Takabe K. Novel Breast Cancer Brain Metastasis Patient-Derived Orthotopic Xenograft Model for Preclinical Studies. Cancers (Basel). 12(2):444, 2020.
15. Pydi SP, Jain S, Barella LF, Zhu L, Sakamoto W, Meister J, Wang L, Lu H, Cui Y, Gavrilova O, Wess J. β-arrestin-1 suppresses myogenic reprogramming of brown fat to maintain euglycemia. Sci Adv. 6(23):eaba1733, 2020.
16. Saito M, Kohno T, Kono K. Heterogeneity of ARID1A expression in gastric cancer may affect patient survival and therapeutic efficacy. Hum Pathol. 101:80-81, 2020.
17. Sakamoto W, Ohki S, Kikuchi K, Okayama H, Fujita S, Endo H, Saito M, Saze Z, Momma T, Kono K. Higher modified Glasgow Prognostic Score and multiple stapler firings for rectal transection are risk factors for anastomotic leakage after low anterior resection in rectal cancer. Fukushima J Med Sci. 66(1):10-16, 2020
18. Sakamoto W, Ohki S, Onozawa H, Okayama H, Endo H, Fujita S, Saito M, Saze Z, Momma T, Takenoshita S Kono S. Long-term outcomes of lower rectal cancer patients treated with total mesorectal excision and lateral pelvic lymph node dissection after preoperative radiotherapy or chemoradiotherapy. Journal of the Anus, Rectum and Colon. 2020.
19. Suzuki K, Gonda K, Kishimoto Y, Katsumoto Y, Takenoshita S. Potential curing and beneficial effects of Ooitabi (Ficus pumila L.) on hypertension and dyslipidaemia in Okinawa. J Hum Nutr Diet. 2020.
20. Ujiie D, Okayama H, Saito K, Ashizawa M, Aung Kyi TM, Endo E, Kase K, Yamada L, Kikuchi T, Hanayama H, Fujita S, Sakamoto W, Endo, H, Saito M, Mimura K, Saze Z, Momma T, Ohki S, Kono K. KRT17 as a prognostic biomarker for stage II colorectal cancer. Carcinogenesis. 41(5):591–599, 2020.
21. Watanabe M, Tachimori Y, Oyama T, Toh Y, Matsubara H, Ueno M, Kono K, Uno T, Ishihara R, Muro K, Numasaki H, Tanaka K, Ozawa S, Murakami K, Usune S, Takahashi A, Miyata H. Registration Committee for Esophageal Cancer of the Japan Esophageal Society. Comprehensive registry of esophageal cancer in Japan, 2013. Esophagus. 18(1):1-24, 2021.
22. Yamada L, Saito M, Min AKT, Saito K, Ashizawa M, Kase K, Nakajima S, Onozawa H, Okayama H, Endo H, Fujita S, Sakamoto W, Saze Z, Momma T, Mimura K, Ohki S, Kono K. Selective sensitivity of EZH2 inhibitors based on synthetic lethality in ARID1A-deficient gastric cancer. Gastric Cancer. 24(1):60-71, 2021.
②総説等
1. Kono K, Nakajima S, Mimura K. Current status of immune checkpoint inhibitors for gastric cancer. Gastric Cancer. 23(4):565-578, 2020.
2. Watanabe T, Shibata M, Soeda S, Furukawa S, Fujimori K, Kono K, Takenoshita S. IL-17A in Ovarian Cancer. Journal of Cancer Therapy. 11(10):605-616, 2020.
③症例報告
1. Hayase S, Sakuma M, Chida T, Saito M, Ami H, Koyama Y, Ohki S, Kono K. Diagnosis and treatment of gastric hamartomatous inverted polyp (GHIP) using a modified combination of laparoscopic and endoscopic approaches to neoplasia with a non-exposure technique (modified CLEAN-NET): a case report. Surg Case Rep. 6(1):200, 2020.
2. Kimura T, Hikichi T, Nakamura J, Takasumi M, Hashimoto M, Kato T, Kobashi R, Takagi T, Suzuki R, Sugimoto M, Sat Y, Irie H, Saze Z, Kobayakawa M, Kono K, Ohira H. Gastric adenocarcinoma with enteroblastic differentiation followed endoscopically: A case report. Clin J Gastroenterol. 13(6):1074-1082, 2020.
3. Ito M, Hirano Y, Isii T, Kondo H, Liming Wang, Asari M, Obara N, Yamaguchi S. Grade 3 well-differentiated neuroendocrine tumor of the rectum: a case report. Surgical Case Reports. 6(1):130, 2020.
4. Yamada L, Saito M, Aita T, Min AKT, Endo E, Kase K, Ujiie D, Hanayama H, Okayama H, Sakamoto W, Endo H, Fujita S, Saze Z, Momma T, Ohki S, Hamaguchi S, Kono K. Tuberculous peritonitis; The effectiveness of diagnostic laparoscopy and the perioperative infectious prevention: A case report. Int J Surg Case Rep. 72:326-329, 2020.
5. 藤田正太郎, 門馬智之, 仲野宏, 山内直人, 山田玲央, 松本拓朗, 菅家康之, 花山寛之, 渡辺洋平, 小野澤寿志, 岡山洋和, 坂本渉, 齋藤元伸, 佐瀬善一郎, 河野浩二. ハイブリッドアプローチで切除し得た骨盤内脂肪肉腫の1例. 癌と化学療法. 47(13):1869-1871, 2020.

(2) 著書・訳書

1. 河野浩二. 生涯教育セミナー記録 2019年度 第27回日本外科学会生涯教育セミナー(東北地区) 「各分野のガイドラインを紐解く」によせて. 日本外科学会雑誌. 121(2): 249. 2020.
2. 河野浩二. 〔私たちの流儀〕第15回 世界を視野に入れ、外科臨床の実践を極めつつ、がん免疫療法の臨床を進める D to D 41:14-17, 2020.
3. 河野浩二. 消化器がん研究の最前線. GICancer Cutting Edge. 2(3):2-3, 2020.
4. 河野浩二. 免疫療法の展望 ニボルマブは今後も3次治療で、単剤で使用すべき薬剤なのか? 臨床外科. 75(10):1190-1194, 2020.
5. 河野浩二. よくわかるがん免疫療法ガイドブック-患者さんとご家族のために-. 監修 2020
6. 柴田昌彦. がん免疫療法の副作用〔総論〕 よくわかるがん免疫療法ガイドブック-患者さんとご家族のために-. 28-31. 2020.
7. 柴田昌彦. 癌と炎症を学ぶ 連載「癌と炎症を学」を終了するにあたり. 消化器外科. 43(12):1709-1710, 2020.
8. 三村耕作. 食道がん. よくわかるがん免疫療法ガイドブック-患者さんとご家族のために-. 58-61, 2020.
9. 三村耕作.その他のがん(脳腫瘍、骨軟部腫瘍、小児がん). よくわかるがん免疫療法ガイドブック-患者さんとご家族のために-. 112-118. 2020
10. 門馬智之. 各分野のガイドラインを紐解く 下部消化管外科領域(大腸)のガイドラインを紐解く. 日本外科学会雑誌. 121(2):252-253, 2020.
11. 門馬智之, 佐久間芽衣, 佐藤孝洋, 小山善久, 河野浩二. 【消化管症候群(第3版)-その他の消化管疾患を含めて-】肛門 腫瘍 直腸肛門部悪性黒色腫. 別冊日本臨床 領域別症候群シリーズ№10 消化管症候群(第3版)Ⅱ-その他の消化管疾患を含めて-. 10:332-335, 2020.
12. 門馬智之, 加瀬晃志, 遠藤英成, 野水整, 河野浩二. 【消化管症候群(第3版)-その他の消化管疾患を含めて-】空腸 回腸 盲腸 結腸 直腸(上) 先天性異常、遺伝性疾患 Turcot症候群. 別冊日本臨床 領域別症候群シリーズ№11 消化管症候群(第3版)Ⅲ-その他の消化管疾患を含めて-. 11:345-348, 2020.
13. 齋藤元伸. 胃癌における免疫チェックポイント阻害剤の効果予測因子と臨床病理学的因子の比較検討 第120回日本外科学会定期学術集会 記録集 7. 2020.
14. 松本拓朗, 河野浩二. 癌と炎症を学ぶ(第7回) Barrett食道癌と炎症. 消化器外科. 43(6):1039-1043, 2020.
15. 仲野宏, 河野浩二. アレルギーのある患者さん. 消化器ナーシング. 25(10):66-71, 2020.
16. 中嶋正太郎, 河野浩二. cutting-edge medicine がん診療の副作用マネジメント 複合がん免疫療法の発展を目指して. Precision medicine. 3(4):299-302, 2020.
17. 大木進司, 河野浩二. 【消化器外科手術の論点2020 誌上ディベートと手術手技】食道外科 食道切除後の標準的再建ルート 後縦隔再建の立場から. 手術. 74(4): 432-438, 2020.
18. 18. 中尾篤人, 井上修, 氏家大輔, 内田萌菜, 柏木麻里子, 香山尚子, 河合利尚, 木村元子, 河野浩二, 佐藤卓哉, 竹田潔, 中嶋正太郎, 中野信浩, 中山俊憲, 中山勝文, 廣瀬晃一, 穂積勝人, 村上正晃, 村上悠二, 八木良二, 松嶋綱治, 山田幸宏. 第10章 腫瘍免疫学と移植免疫学 がん細胞と正常非自己細胞に対する免疫応答 基礎免疫学 原著第6版 免疫系の機能とその異常. 185-205, 2020.

(3) 知的財産権

1. 氏家大輔, 岡山洋和, 河野浩二. 国際出願番号 :PCT/JP2020/004474 発明の名称:COLON CANCER PROGNOSIS BIOMARKER.

業績集 消化管外科学講座 令和元年(2019年)

(分類は大学の業績集に準じています)

(1) 論文

①原著 (筆頭著者のイニシアル順)
1. Ashizawa M, Okayama H, Ishigame T, Aung Kyi TM, Saito K, Ujiie D, Murakami Y, Kikuchi T, Nakayama Y, Noda M, Tada T, Endo H, Fujita S, Sakamoto W, Saito M, Saze Z, Momma T, Ohki S, Mimura K, Kono K. miRNA-148a-3p Regulates Immunosuppression in DNA Mismatch Repair-Deficient Colorectal Cancer by Targeting PD-L1. Mol Cancer Res. 17(6): 1403-1413, 2019.
2. Ashizawa M, Saito M, Aung Kyi TM, Ujiie D, Saito K, Sato T, Kikuchi T, Okayama H, Fujita S, Endo H, Sakamoto W, Momma T, Ohki S, Goto A, Kono K. Prognostic role of ARID1A negative expression in gastric cancer. Sci Rep. 1(9): 6769, 2019.
3. Gonda K, Yaginuma K, Rokkaku Y, Horita S, Maejima Y, Shimomura K. Association between cognitive impairment patient with solid cancer and insulin resistance. BMC Res Notes. 12(1): 705, 2019.
4. Hayase S, Yamada L, Ujiie D, Nirei A, Tada T, Hanayama H, Momma T, Saze Z, Ohki S, Kono K. Clinical usefulness of ramucirumab plus paclitaxel for unresectable and recurrent gastric cancer. Fukushima J Med Sci. 65(1): 6-12, 2019.
5. Ishimaru K, Nakajima S, Yu G, Nakamura Y, Nakao A. The Putatively Specific Synthetic REV-ERB Agonist SR9009 Inhibits IgE- and IL-33-Mediated Mast Cell Activation Independently of the Circadian Clock. Int J Mo Sci. 20(24), 2019.
6. Ito T, Kono K, Eguchi H, Okazaki Y, Yamamoto G, Tachikawa T, Akagi K, Okada Y, Kawakami S, Morozumi M, Tamaru J, Ishida H. Prevalence of Lynch syndrome among patients with upper urinary tract carcinoma in a Japanese hospital-based population. Jpn J Clin Oncol. 2019.
7. Kanke Y, Saito M, Abe N, Saito K, Goto A, Ohtake T, Murakami Y, Kono K. Expression profile of CADM1 and CADM4 in triple negative breast cancer with primary systemic therapy. Oncol Lett. 17(1): 921-926, 2019.
8. Kikuchi T, Mimura K, Ashizawa M, Okayama H, Endo E, Saito K, Sakamoto W, Fujita S, Endo H, Saito M, Momma T, Saze Z, Ohki S, Shimada K, Yoshimura K, Tsunoda T, Kono K. Characterization of tumor-infiltrating immune cells in relation to microbiota in colorectal cancers. Cancer Immunol Immunother. 69(1): 23-32, 2020.
9. Kikuchi T, Mimura K, Okayama H, Nakayama Y, Saito K, Yamada L, Endo E, Sakamoto W, Fujita S, Endo H, Saito M, Momma T, Saze Z, Ohki S, Kono K. A subset of patients with MSS/MSI-low-colorectal cancer showed increased CD8(+) TILs together with up-regulated IFN-γ. Oncol Lett. 18(6): 59775985, 2019.
10. Minamikawa K, Okumura A, Kokudo N, Kono K. Regulation on introducing process of the highly difficult new medical technologies: A survey on the current status of practice guidelines in Japan and overseas. Biosci Trends. 12(6): 560-568, 2019.
11. Nakajima S, Ishimaru K, Kobayashi A, Yu G, Nakamura Y, Oh-oka Y, Suzuki-Inoue K, Kono K, Nakao A. Resveratrol inhibits IL-33-mediated mast cell activation by targeting the MK2/3-PI3K/Akt axis. Sci Rep. 9(1): 18423, 2019.
12. Nakayama Y, Mimura K, Takamaki T, Shiraishi K, Kua LF, Koh V, Ohmomri M, Kimura A, Inoue S, Okayama H, Suzuki Y, Kanazawa T, Ujiie D, Kono K. PhosphoSTAT1 expression as a potential biomarker for antiPD1/antiPDL1 immunotherapy for breast cancer. Int J Oncol. 54(6): 2030-2038, 2019.
13. Okano M, Oshi M, Butash AL, Katsuta E, Tachibana K, Saito K, Okayama H, Peng X, Yan L, Kono K, Ohtake T, Takabe K. Triple-Negative Breast Cancer with High Levels of Annexin A1 Expression Is Associated with Mast Cell Infiltration, Inflammation, and Angiogenesis. Int J Mol Sci. 20(17): 4197,2019.
14. Okonogi N, Suzuki Y, Sato H, Oike T, Yoshimoto Y, Mimura K, Noda SE, Okamoto M, Tamaki T, Morokoshi Y, Hasegawa S, Ohgaki H, Yokoo H, Nakano T. In Reply to Minhas and Tran. Int J Radiat Oncol Bio Phys. 104(1): 223-224 ,2019.
15. Pydi SP, Jain S, Tung W, Cui Y, Zhu L, Sakamoto W, Jain S, Abel BS, Skarulis MC, Liu J, Huynh T, Pacak K, Caron MG, Gavrilova O, Finkel T, Wess J. Adipocyte β-arrestin-2 is essential for maintaining whole body glucose and energy homeostasis. Nat Commun. 10(1): 2936, 2019.
16. Sakamoto W, Yamada L, Suzuki O, Kikuchi T, Okayama H, Endo H, Fujita S, Saito M, Momma T, Saze Z, Ohki S, Kono K. Microanatomy of inferior mesenteric artery sheath in colorectal cancer surgery. J Anus Rectum Colon. 3(4): 167-174, 2019.
17. Satake S, Shimura T, Ono T, Shimomura K, Takenoshita S,Kono K. Noninvasive continuous blood pressure monitoring using microelectromechanical system technology. Blood Press Monit. 24(3): 155-159, 2019.
18. Shimura T, Shibata M,Gonda K, Murakami Y, Noda M, Tachibana K, Abe N, Ohtake T. Prognostic impact of interleukin-6 and C-reactive protein on patients with breast cancer. Oncol Lett. 17(6): 5139-5146, 2019.
19. Soeda S, Furukawa S, Sato T, Ueda M, Kamo N, Endo Y, Kojima M, Nomura S, Kataoka M, Fujita S, Endo H, Takahashi T, Watanabe T, Yamada H, Fujimori K. Pelvic Exenteration as Potential Cure and Symptom Relief in Advanced and Recurrent Gynaecological Cancer. Anticancer Res. 39(10): 5631-5637, 2019.
20. Tan YJ, Lee YT, Petersen SH, Kaur G, Kono K, Tan SC, Majid AMSA, Oon CE. BZD9L1 sirtuin inhibitor as a potential adjuvant for sensitization of colorectal cancer cells to 5-fluorouracil. Ther Adv Med Oncol. 11: 1-25, 2019.
21. Ujiie D, Okayama H, Saito K, Ashizawa M, Aung Kyi TM, Endo E, Kase K, Yamada L, Kikuchi T, Hanayama H, Fujita S, Sakamoto W, Endo, H, Saito M, Mimura K, Saze Z, Momma T, Ohki S, Kono K. KRT17 as a prognostic biomarker for stage II colorectal cancer. Carcinogenesis. 2019.
22. Yamada L, Saito M, Aung Kyi TM, Saito K, Kase K, Onozawa H, Okayama H, Fujita S, Endo H, Sakamoto W, Saze Z, Momma T, Ohki S, Mimura K, Kono K. Explore the correlation between ARID1A and ANXA1 expressions in gastric cancer. Ann. Cancer Res.Ther. 27(2):48-51, 2019.
1. 木村隆, 横山斉, 鈴木眞一, 河野浩二, 丸橋 繁, 鈴木弘行, 大竹徹, 田中秀明. 外科医となる自信を涵養する外科臨床実習-時代にマッチした外科医のリクルート-. 日本外科学会雑誌. 80(12): 2175-2182, 2019.
②総説等
1. Saito M, Kono K, Kohno T. Molecular Genetics of Thymic Carcinoma. eLS. 2019.
2. Shibata M, Mimura K, Shimura T, Kono K, Ohto H, Takenoshita S. IL-17A in oncology. Ann. Cancer Res. Ther. 27(2): 59-63, 2019.
③症例報告
1. Asano T, Sato S, Furuya MY, Takahashi H, Shichishima-Nakamura A, Ohkawara H, Fujiwara T, Gunji N, Hashimoto C, Momma T, Saito M, Nakano H, Watanabe G, Temmoku J, Fujita Y, Matsuoka N, Kobayashi H, Watanabe H, Mouri M, Mashiyama F, Sakuma H, Ohira H, Mori M, Ikezoe T, Migita K. Intestinal Behcet disease associated with myelodysplastic syndrome accompanying trisomy 8 successfully treated with abdominal surgery followed by hematopoietic stem cell transplantation: A case report. Medicine. 98(46): e17979, 2019.
2. Gonda K, Akama T, Nakamura T, Hashimoto E, Kyoya N, Rokkaku Y, Maejima Y, Horita S, Tachibana K, Abe N, Ohtake T, Shimomura K, Kono K, Saji S, Takenoshita S, Higashihara E. Cluster of differentiation 8 and programmed cell death ligand 1 expression in triple-negative breast cancer combined with autosomal dominant polycystic kidney disease and tuberous sclerosis complex: a case report. J Med Case Rep. 13(1): 381. 2019.
3. Kawashima K, Fujiwara T, Katakura K, Gunji N, Yokokawa A, Sakamoto W, Hikichi T, Kono K, Ohira H. A Case of Anisakiasis in the Small Intestine with Excessive Bleeding That was Difficult to Diagnose Endoscopically. Internal Medicine. 58(1): 63-66,2019.
4. Momma T, Gonda K, Akama Y, Endo E, Ujiie D, Fujita S, Maejima Y, Horita S, Shimomura K, Saji S, Kono K, Yashima R, Watanabe F, Sugano K, Nomizu T. MLH1 germline mutation associated with Lynch syndromae in a family followed for more than 45 years. BMC Medical Genetics. 20: 67, 2019.
5. 深井智司, 絹田俊爾, 林嗣博, 滝口光一, 羽成直行, 輿石直樹. 腹腔鏡下幽門側胃切除術を施行した左胃動脈・冠動脈交通を伴う胃癌の1例. 日本臨床外科学会雑誌. 80(1): 67-73, 2019.
6. 藤田正太郎, 門馬智之, 佐藤孝洋, 遠藤英成, 加瀬晃志, 氏家大輔, 菊池智宏, 楡井東, 花山寛之, 渡辺洋平, 岡山洋和, 坂本渉, 遠藤久仁, 齋藤元伸, 佐瀬善一郎, 大木進司, 河野浩二. 直腸癌術後の直腸膣痩に対しエストリオール膣錠と膣洗浄にて治癒した1例. 癌と化学療法 . 46(13): 2078-2080, 2019.
7. 松井田元, 土屋貴男, 齋藤敬弘, 大谷聡, 伊東藤男, 三浦純一. 内視鏡治療により治癒し得た魚骨によるS状結腸穿通の1例. 福島医学雑誌. 69(2): 161-166, 2019.
8. 松本拓朗, 大木進司, 門馬智之, 喜古雄一郎, 田﨑和洋, 河野浩二. 小網原発GISTの2例. 日本臨床外科学会雑誌. 80(12): 2175-2182, 2019.
9. 松本拓朗, 圓谷秀哲, 伊藤泰輔, 石井芳正, 小田島肇, 河野浩二. 胃びまん性大細胞型B細胞性リンパ腫に併存した胃GISTの1例. 日本臨床外科学会雑誌. 80(11): 2006-2012, 2019.

(2) 著書・訳書

1. Kitagawa Y, Uno T, Oyama T, Kato K, Kato H, Kawakubo H, Kawamura O, Kusano M, Kuwano H, Takeuchi H, Toh Y, Doki Y, Naomoto Y, Nemoto K, Booka E, Matsubara H, Miyazaki T, Muto M, Yanagisawa A, Yoshida M. Esophageal cancer practice guidelines 2017 edited by the Japan esophageal society: part 1. Esophagus. 16(1): 1-24, 2019.
2. Kitagawa Y, Uno T, Oyama T, Kato K, Kato H, Kawakubo H, Kawamura O, Kusano M, Kuwano H, Takeuchi H, Toh Y, Doki Y, Naomoto Y, Nemoto K, Booka E, Matsubara H, Miyazaki T, Muto M, Yanagisawa A, Yoshida M. Esophageal cancer practice guidelines 2017 edited by the Japan esophageal society: part 2. Esophagus. 16(1): 25-43, 2019.
3. 大木進司, 氏家大輔, 松本拓朗, 仲野宏, 河野浩二. EBウィルス関連胃癌. 別冊 日本臨床 領域別症候群シリーズ No.9 消化管症候群(第3版)Ⅰ -その他の消化管疾患を含めて-. 284-287, 2019.
4. 河野浩二, 柴田昌彦. 【癌免疫カンファレンスルーム】連載を終えるにあたって. 消化器外科. 42(11): 1610-1611, 2019.
5. 河野浩二, 南川一夫, 冨樫順一, 長谷川潔, 國土典宏. 【医療機器・介護機器開発を正しくおこなうための関連法とガイドラインの理解】高難度新規医療技術の導入プロセスが制度化された背景について. 医療機器学. 89(4): 383-387, 2019.
6. 佐瀬善一郎, 河野浩二. 【最新の診断技術】食道癌リンパ節転移診断の進歩. 日本外科学会雑誌. 120(3): 343-344, 2019.
7. 柴田昌彦. 【癌と炎症を学ぶ第1回】“癌と炎症” 概説;連載の序にかえて. 消化器外科. 42(12): 1723-1729, 2019.
8. 中山裕子, 三村耕作, 河野浩二. 【がんにおけるPD-L1分子の発現調節】IFN-γの観点からみたPD-L1発現機構と抗PD-1/抗PD-L1抗体のバイオマーカー開発. 癌と化学療法. 46(5): 838-840, 2019.

(3) 知的財産権

1. 氏家大輔, 岡山洋和, 河野浩二. 出願番号:特願2019-021987 発明の名称:大腸がんの予後バイオマーカー.
2. 竹之下誠一, 大木進司. 特許第6618468号 発明の名称:能動鉗子.

業績集 消化管外科学講座 平成30年(2018年)

(分類は大学の業績集に準じています)

(1) 論文

①原著 (筆頭著者のイニシアル順)
1. Ando K, Suzuki Y, Kaminuma T, Yoshimoto Y, Oike T, Okonogi N, Sato H, Tamaki T, Noda SE, Mimura K, Nakano T.  Tumor-specific CD8-positive T cell-mediated antitumor immunity is implicated in the antitumor effect of local hyperthermia. Int J Hyperthermia. 35(1):226-231, 2018.
2. Aoto K, Mimura K, Okayama H, Saito M, Chida S, Noda M, Nakajima T, Saito K, Abe N, Ohki S, Ohtake T, Takenoshita S, Kono K. Immunogenic tumor cell death induced by chemotherapy in patients with breast cancer and esophageal squamous cell carcinoma. Oncol Rep. 39(1): 151-159, 2018.
3. Fujiwara Y, Saito M, Robles AI, Nishida M, Takeshita F, Watanabe M, Ochiya T, Yokota J, Kohno T, Harris CC, Tsuchiya N. A Nucleolar Stress-Specific p53-miR-101 Molecular Circuit Functions as an Intrinsic Tumor-Suppressor Network. EBioMedicine. 33: 33-48, 2018.
4. Kanke Y, Shimomura A, Saito M, Honda T, Shiraishi K, Shimada Y, Watanabe R, Yoshida H, Yoshida M, Shimizu C, Takahashi K, Totsuka H, Ogiwara H, Hirose S, Kono K, Tamura K, Okamoto A, Kinoshita T, Kato T, Kohno T. Gene aberration profile of tumors of adolescent and young adult females. Oncotarget. 29; 9(5): 6228-6237. 2017.
5. Kawamura H, Honda M, Takiguchi K, Kamiga T, Saito K, Yamazaki S, Muto A, Shiraso S, Yamashita N, Iwao T, Saji S, Kono K. Development of a prognostic nomogram for metastatic colorectal cancer patients: The study protocol of a multicenter, retrospective, observational, cohort study. Ann. Cancer Res. Ther. 26(2): 116-119, 2018.
6. Kikuchi D, Saito M, Saito K, Watanabe Y, Matsumoto Y, Kanke Y, Onozawa H, Hayase S, Sakamoto W, Ishigame T, Momma T, Ohki S, Takenoshita S. Upregulated solute carrier family 37 member 1 in colorectal cancer is associated with poor patient outcome and metastasis. Oncol Lett. 15(2): 2065-2072, 2018.
7. Lau WM, Teng E, Huang KK, Tan JW, Das K, Zang Z, Chia T, The M, Kono K, Yong WP, Shabbir A, Tay A, Phua NS, Tan P, Chan SL, So JBY. Acquired Resistance to FGFR Inhibitor in Diffuse-Type Gastric Cancer through an AKT-Independent PKC-Mediated Phosphorylation of GSK3b. Mol Cancer Ther. 17(1): 232-242, 2018.
8. Lim KS, Mimura K, Kua LF, Shiraishi K, Kono K. Implication of Highly Cytotoxic Natural Killer Cells for Esophageal Squamous Cell Carcinoma Treatment. J Immunother. 41(6): 261-273, 2018.
9. Li Z, Maeda D, Yoshida M, Umakoshi M, Nanjo H, Shiraishi K, Saito M, Kohno T, Konno H, Saito H, Minamiya Y, Goto A. The intratumoral distribution influences the prognostic impact of CD68- and CD204-positive macrophages in non-small cell lung cancer. Lung Cancer. 123: 127-135, 2018.
10. Matsumoto Y, Saito M, Saito K, Kanke Y, Watanabe Y, Onozawa H, Hayase S, Sakamoto W, Ishigame T, Momma T, Kumamoto K, Ohki S, Takenoshita S. Enhanced expression of KIF4A in colorectal cancer is associated with lymph node metastasis. Oncol Lett. 15(2): 2188-2194, 2018.
11. Minamikawa K, Shibata M, Gonda K, Ujiie D, Ashizawa M, Nakajima T, Okayama H, Sakamoto W, Saito M, Momma M, Mimura M, Ohki S, Shimura T, Ohto H, Takenoshita S, Kono K. IL-17 and VEGF are significantly associated with disease progression involving systemic inflammation in patients with gastric and colorectal cancers. Ann. Cancer Res. Ther. Vol. 25, No. 2, pp. 67-76, 2017.
12. Mimura K, Teh JL, Okayama H, Shiraishi K, Kua LF, Koh V, Smoot DT, Ashktorab H, Oike T, Suzuki Y, Fazreen Z, Asuncion BR, Shabbir A, Yong WP, So J, Soong R, Kono K. PD-L1 expression is mainly regulated by interferon gamma associated with JAK-STAT pathway in gastric cancer. Cancer Sci. 109(1): 43-53, 2018.
13. Minamikawa K, Okumura A, Kokudo N, Kono K. Regulation on introducing process of the highly difficult new medical technologies: A survey on the current status of practice guidelines in Japan and overseas. Biosci Trends. 12(6): 560-568,2018
14. Nakajima T, Okayama H, Ashizawa M, Noda M, Aoto K, Saito M, Monma T, Ohki S, Shibata M, Takenoshita S, Kono K. Augmentation of antibody-dependent cellular cytotoxicity with defucosylated monoclonal antibodies in patients with GI-tract cancer. Oncol Lett. 15(2): 2604-2610, 2018.
15. Noda M, Okayama H, Kofunato Y, Chida S, Saito K, Tada T, Ashizawa M, Nakajima T, Aoto K, Kikuchi T, Sakamoto W, Endo H, Fujita S, Saito M, Momma T, Ohki S, Kono K. Prognostic role of FUT8 expression in relation to p53 status in stage II and III colorectal cancer. PLoS One. 13(7): e0200315, 2018.
16. Noda M, Okayama H, Tachibana K, Sakamoto W, Saito K, Thar Min AK, Ashizawa M, Nakajima T, Aoto K, Momma T, Katakura K, Ohki S, Kono K. Glycosyltransferase Gene Expression Identifies a Poor Prognostic Colorectal Cancer Subtype Associated with Mismatch Repair Deficiency and Incomplete Glycan Synthesis. Clin Cancer Res. 24(18): 4468-4481, 2018.
17. Nohara K, Yamada K, Yamada L, Hagiwara T, Igari T, Yokoi C, Soma D, Yamashita S, Dohi T, Kawamura YI. Expression of kallikrein-related peptidase 13 is associated with poor prognosis in esophageal squamous cell carcinoma. Gen Thorac Cardiovasc Surg. 66(6): 351-357, 2018.
18. Okonogi N, Suzuki Y, Sato H, Oike T, Yoshimoto Y, Mimura K, Noda SE, Okamoto M, Tamaki T, Morokoshi Y, Hasegawa S, Ohgaki H, Yokoo H, Nakano T. Combination Therapy of Intravenously Injected Microglia and Radiation Therapy Prolongs Survival in a Rat Model of Spontaneous Malignant Glioma. Int J Radiat Oncol Biol Phys.102(3): 601-608, 2018.
19. Osanai-Sasakawa A, Hosomi K, Sumitomo Y, Takizawa T, Tomura-Suruki S, Imaizumi M, Kasai N, Poh TW, Yamano K, Yong WP, Kono K, Nakamura S, Ishii T, Nakai R. An anti-ASCT2 monoclonal antibody suppresses gastric cancer growth by inducing oxidative stress and antibody dependent cellular toxicity in preclinical models. Am J Cancer Res. 8(8): 1499-1513, 2018.
20. Saito M, Goto A, Abe N, Saito K, Maeda D, Ohtake T, Murakami Y, Takenoshita S. Decreased expression of CADM1 and CADM4 are associated with advanced stage breast cancer. Oncol Lett. 15(2): 2401-2406, 2018.
21. Saito M, Saito K, Nakano H, Kikuchu T, Okayama H, Fujita S, Endo H, Sakamoto H, Momma T, Ohki S, Kono K. Annexin A1 is upregulated in p53-positive gastric cancer. Ann. Cancer Res. Ther. 26(1): 26-30, 2018.
22. Saito M, Saito K, Shiraishi K, Maeda D, Suzuki H, Minamiya Y, Kono K, Kohno T, Goto A. Identification of candidate responders for anti-PD-L1/PD-1 immunotherapy, Rova-T therapy, or EZH2 inhibitory therapy in small-cell lung cancer. Mol Clin Oncol. 8(2): 310-314, 2018.
23. Sawamura Y, Ohto H, Ikeda K, Kanno T, Suzuki Y, Gonda K, Tasaki T, Nollet K.E, Takahashi H, Aota S. Impact of prestorage leucoreduction of autologous whole blood on length of hospital stay with a subgroup analysis in bilateral hip arthroplasty. Vox Sang. 2018 Jun 20. doi: 10.1111/vox.12674.
24. Shimura T, Shibata M, Gonda K, Hayase S, Sakamoto W, Okayama H, Fujita S, Saito M, Momma T, Ohki S, Kono K. Prognostic impact of preoperative lymphocyte-to-monocyte ratio in patients with colorectal cancer with special reference to myeloid-derived suppressor cells. Fukushima J Med Sci. 64(2): 64-72, 2018.
25. Shimura T, Shibata M, Gonda K, Kofunato Y, Ishigame T, Okada R, Sato N, Kimura T, Kenjo A, Marubashi S. Prognostic impact of soluble intercellular adhesion molecule-1 in hepatocellular carcinoma. Oncol Lett. 16(5): 6013-6018, 2018.
26. Shimura T, Shibata M, Gonda K, Matsumoto Y, Nakano K, Iwadate M, Suzuki S, Suzuki S. Prognostic impact of elevated preoperative C-reactive protein on patients with differentiated thyroid carcinoma. J Surg Res. 231: 338-345, 2018.
27. Shimura T, Shibata M, Gonda K, Okayama H, Saito M, Momma T, Ohki S, Kono K. Serum transthyretin level is associated with prognosis of patients with gastric cancer. J Surg Res. 227: 145-150, 2018.
28. Shimura T, Shibata M, Kofunato Y, Okada R, Ishigame T, Kimura T, Kenjo A, Marubashi S. Clinical significance of serum transthyretin level in patients with hepatocellular carcinoma. ANZ J Surg. 88(12): 1328-1332, 2018.
29. Sundar R, Rha SY, Yamaue H, Katsuda M, Kono K, Kim HS, Kim C, Mimura K, Kua LF, Yong WP. A phase I/Ib study of OTSGC-A24 combined peptide vaccine in advanced gastric cancer. BMC Cancer. 18(1): 332, 2018.
30. Tan YJ, Lee YT, Yeong KY, Petersen SH, Kono K, Tan SC, Oon CE. Anticancer activities of a benzimidazole compound through sirtuin inhibition in colorectal cancer. Future Med Chem. 10(17): 2039-2057, 2018.
31. Thar Min AK, Okayama H, Saito M, Ashizawa M, Aoto K, Nakajima T, Saito K, Hayase S, Sakamoto W, Tada T, Hanayama H, Saze Z, Momma T, Ohki S, Sato Y, Motoyama S, Mimura K, Kono K. Epithelial-mesenchymal transition-converted tumor cells can induce T-cell apoptosis through upregulation of programmed death ligand 1 expression in esophageal squamous cell carcinoma. Cancer Med. 7: 3321-3330, 2018.
32. Watanabe Y, Saito M, Saito K, Matsumoto Y, Kanke Y, Onozawa H, Hayase S, Sakamoto W, Ishigame T, Momma T, Ohki S, Takenoshita S. Upregulated HOXA9 expression is associated with lymph node metastasis in colorectal cancer. Oncol Lett. 15(3): 2756-2762, 2018.
②総説等
1. Kono K. Advances in cancer immunotherapy for gastroenterological malignancy. Ann Gastroenterol Surg. 2: 244-245, 2018.
2. Kono K, Mimura K, Yamada R, Ujiie D, Hayase S, Tada T, Okayama H, Thar Min AK, Shibata M, Momma T, Saze Z, Ohki S. Current status of cancer immunotherapy for esophageal squamous cell carcinoma. Esophagus. 15(Issue1): 1-9, 2018.
3. Mimura K, Yamada L, Ujiie D, Hayase S, Tada T, Hanayama H, Thar Min AK, Shibata M, Momma T, Saze Z, Ohki S, Kono K. Immunotherapy for esophageal squamous cell carcinoma : a review. Fukushima J. Med. Sci. 64(2): 46-53, 2018.
4. Okayama H, Noda M, Kono K. Aberrant glycosylation in colorectal cancer with genomic and epigenomic alterations. Oncotarget. 9(86): 35609-35610, 2018.
5. Saito M, Kono K, Kohno T. Identification of a novel therapeutic target in driver-negative non-small cell lung cancer. Transl Lung Cancer Res. 7(Suppl 3): S218-S220, 2018.
6. Saito M, Momma T, Kono K. Targeted therapy according to next generation sequencing-based panel sequencing. Fukushima J Med Sci. 64(1): 9-14, 2018.
7. Saito M, Shiraishi K, Goto A, Suzuki H, Kohno T, Kono K. Development of targeted therapy and immunotherapy for treatment of small cell lung cancer. Jpn J Clin Oncol. 48(7): 603-608, 2018.
8. Saito M, Suzuki H, Kono K, Takenoshita S, Kohno T. Treatment of lung adenocarcinoma by molecular-targeted therapy and immunotherapy. Surgery Today. 48(1): 1-8, 2018.
9. Shibata M, Gonda K, Shimura T, Sakurai K, Takenoshita S. SIRS, CARS and MARS in relationship to cancer cachexia and its clinical implications. Ann. Cancer Res. Ther. 26( 1): 54-59, 2018.
10. Yehya AHS, Asif M, Petersen SH, Subramaniam AV, Kono K, Majid AMSA, Oon CE. Angiogenesis: Managing the Culprits behind Tumorigenesis and Metastasis. Medicina. 54(1):8, 2018.
11.
1. 柴田昌彦, 権田憲士, 三村耕作, 河野浩二, 大戸斉, 竹之下誠一. 骨髄由来免疫細(MDSC)と腫瘍抑制. 炎症と免疫. 26(2): 15-21
2. 三村耕作. テトラマー解説. 消化器外科. 41(2): 199-201, 2018.
③症例報告
1. Azuhata T, Shibata M, Nakamura K, Kawano D, Terakado Y, Azuhata I, Sakurai A, Yamada T, Sugita K, Tomita R, Tsuyama Y, Tanjoh K, Azuhata S. A case of clinical complete response of colorectal liver metastasis following chemotherapy with S-1 and oxaliplatin (SOX) in combination with bevacizumab. Ann. Cancer Res. Ther. 26(2): 101-104, 2018.
2. Gonda K, Tachiya Y, Hatakeyama Y, Momma T, Tamaoki T, Maejima Y, Rokkaku Y, Saji S, Shimomura K, Kono K. Poland syndrome accompanied by internal iliac artery supply disruption sequence: a case report. J Med Case Rep. 12(1): 312, 2018.
3. 青砥慶太, 松本進, 井上典夫. FOLFOX で長期cCR を得た再発大腸癌の1例. 癌と化学療法. 45(13): 2258-2260, 2018
4. 氏家大輔, 小野澤寿志, 遠藤英成, 千田峻, 渡辺洋平, 岡山洋和, 斎藤勝, 門馬智之, 佐瀬善一郎, 大木進司, 金澤匡司, 河野浩二. HALSで修復した絞扼を伴う成人Bochdalek孔ヘルニア小腸嵌頓の1例. 福島医学雑誌. 68(3): 173-176, 2018.
5. 氏家大輔, 加瀬晃志, 早瀬傑, 坂本渉, 藤田正太郎, 門馬智之, 佐瀬善一郎, 大木進司, 河野浩二. 胃管癌に対する陽子線照射後の再発例に対し胃管切除を実施した1例. 癌と化学療法. 45(13): 1946-1948, 2018.
6. 大木進司, 引地拓人, 門馬智之, 渡辺晃, 中村純, 菊地眸, 山田玲央, 氏家大輔, 楡井東, 多田武志, 花山寬之, 渡辺洋平, 早瀬傑, 権田憲士, 佐瀬善一郎, 河野浩二. 十二指腸腫瘍に対する腹腔鏡内視鏡合同手術(LECS)の応用. 癌と化学療法. 45(13): 2024-2026, 2018.
7. 権田憲士, 菊池智宏, 柴田昌彦, 畠山優一, 立谷陽介, 六角裕一, 遠藤久仁, 藤田正太郎, 坂本渉, 早瀬傑, 岡山洋和, 花山寬之, 多田武志, 楡井東, 氏家大輔, 山田玲央, 佐瀬善一郎, 門馬智之, 大木進司, 河野浩二. 傍腫瘍性小脳変性症に直腸癌を合併した1例. 癌と化学療法. 45(10): 1510-1512, 2018.
8. 権田憲士, 藤田正太郎, 柴田昌彦, 畠山優一, 立谷陽介, 六角裕一, 佐瀬善一郎, 門馬智之, 大木進司, 佐治重衡, 河野浩二. 大腸癌再発症例にAfliberceptを投与しPRを得た症例. 癌と化学療法. 45(10): 1539-1542, 2018.
9. 千田峻, 加瀬晃志, 八島玲, 片方直人, 渡辺文明, 野水整, 河野浩二. 結腸癌術後にドレーン部と吻合部に同時再発した1例. 癌と化学療法. 45(13): 1883-1885, 2018.
10. 中山裕子, 井上慎吾, 三村耕作, 中澤匡男, 木村亜矢子, 大森征人, 松田啓, 市川大輔. S-1が有効であったトリプルネガティブ乳癌の1例. 癌と化学療法. 45(9): 1343-1346, 2018.
11. 藤田正太郎, 大木進司, 早瀬傑, 氏家大輔, 菊池智宏, 多田武志, 花山寬之, 岡山洋和, 坂本渉, 遠藤久仁, 齋藤元伸, 権田憲士, 佐瀬善一郎, 門馬智之, 河野浩二. 根治的化学放射線療法で完全寛解して6年後に頸部リンパ節再発した食道癌の1例. 癌と化学療法. 45(13): 1821-1823, 2018.
12. 村上祐子, 門馬智之, 立花和之進, 長塚美樹, 松嵜正實, 野水整. 神経線維腫症1型および完全内臓逆位症を伴った異時性両側乳癌の1例. 日臨外会誌. 79( 2 ): 302-307, 2018.

(2) 著書・訳書

1. 大木進司, 河野浩二. 術野の消毒. 5年でマスター消化器外科標準手術 消化器外科専門医への道: 6-9, 2018.
2. 河野浩二, 大木進司, 佐瀬善一郎, 仲野宏, 山田玲央, 氏家大輔, 楡井東, 花山寬之, 早瀬傑, 多田武志, 権田憲士, 門馬智之. 腹臥位鏡視下食道切除術-手術の定型化-. 消化器外科 手術アトラス.41(8): 1113-1123, 2018.
3. 中山裕子, 三村耕作, 河野浩二. 免疫チェックポイント阻害薬(解説/特集). 日本臨床76巻増刊8 食道癌, 474-480, 2018.

(3) 知的財産権

1. 岡山洋和, 野田勝, 河野浩二. 国際出願番号 :PCT/JP2018/032628. 発明の名称:大腸がんの予後バイオマーカー.

業績集 消化管外科学講座 平成29年(2017年)

(1) 論文

①原著(筆頭著者のイニシアル順)
1. Ando J*, Saito M*, Imai J, Ito E, Yanagisawa, Honma R, Saito K*, Tachibana K, Momma T*, Ohki S*, Ohtake T, Watanabe S, Waguri S, Kono K*,Takenoshita S. TBX19 is overexpressed in colorectal cancer and associated with lymph node metastasis. Fukushima J Med Sci. 63(3): 141-151, 2017.
2. George J, Saito M*, Tsuta K, Iwakawa R, Shiraishi K, Scheel AH, Uchida S, Watanabe SI, Nishikawa R, Noguchi M, Peifer M, Jang SJ, Petersen I, Buttner R, Harris CC, Yokota J, Thomas RK, Kohno T. (co-first author) Genomic Amplification of CD274 (PD-L1) in Small-Cell Lung Cancer. Clin Cancer Res. 23(5):1220-1226, 2017.
3. Gonda K*, Shibata M*, Ohtake T, Matsumoto Y, Tachibana K, Abe N, Ohto H, Sakurai K, Takenoshita S. Myeloid-derived suppressor cells are increased and correlated with type 2 immune responses, malnutrition, inflammation, and poor prognosis in patients with breast cancer. Oncol Lett. 14(2):1766-1774, 2017.
4. Gonda K, Shibata M, Sato Y, Washio M, Takeshita H, Shigeta H, Ogura M, Oka S, Sakuramoto S. Elevated neutrophil to lumphocyte ratio is associated with nutritional impairment, immune suppression, resistance to S-1 plus cisplatin, and poor prognosis in patients with stage IV gastric cancer. Mol Clin Oncol. 7(6): 1073-1078, 2017.
5. Goto A, Tanaka M, Yoshida M, Umakoshi M, Nanjo H, Shiraishi K, Saito M*, Kohno T, Kuriyama S, Konno H, Imai K, Saito H, Minamiya Y, Maeda D. The low expression of miR-451 predicts a worse prognosis in non-small cell lung cancer cases. PLoS One. 12(7):e0181270, 2017.
6. Hayase S*, Kumamoto K*, Saito K*, Kofunato Y, Sato Y*, Okayama H*, Miyamoto K*, Ohki S*, Takenoshita S. L?type amino acid transporter 1 expression is upregulated and associated with cellular proliferation in colorectal cancer. Oncol Lett. 14(6): 7410-7416, 2017.
7. Hayashi H, Kohno T, Ueno H, Hiraoka N, Kondo S, Saito M*, Ichikawa H, Kato M, Shibata T, Morizane C, Sakamoto T, Shimada K, Komatsu Y, Sakamoto N, Okusaka T. The number of mutations among KRAS, CDKN2A, TP53, and SMAD4 as detected using targeted deep sequencing is a useful prognostic biomarker for pancreatic cancer. Pancreas 46(3):335-340, 2017.
8. Kasai N, Sasakawa A, Hosomi K, Poh TW, Chua BL, Yong WP, So J, Chan SL, Soong R, Kono K*, Ishii T, Yamano K. Anti-tumor efficacy evaluation of a novel monoclonal antibody targeting neutral amino acid transporter ASCT2 using patient-derived xenograft mouse models of gastric cancer. Am J Transl Res. 9(7):3399-3410, 2017.
9. Kogashiwa Y, Yasuda M, Sakurai H, Nakahira M, Sano Y, Gonda K*, Ikeda T, Inoue H, Kuba K, Oba S, Ishikawa J, Enoki Y, Matsumura S, Minami K, Ebihara Y, Sugasawa M. PD-L1 Expression Confers Better Prognosis in Locally Advanced Oral Squamous Cell Carcinoma. Anticancer Res. 37(3):1417-1424, 2017.
10. Kumamoto K, Endo S, Isohata N, Nirei A*, Nemoto D, Utano K, Saito T, Togashi K. Pseudocirrhosis caused by regorafenib in an advanced rectal cancer patient with multiple liver metastases. Mol Clin Oncol. 6(1):63-66, 2017.
11. Kunisaki C, Miyata H, Konno H, Saze Z*, Hirahara N, Kikuchi H, Wakabayashi G, Gotoh M, Mori M. Modeling preoperative risk factors for potentially lethal morbidities using a nationwide Japanese web-based database of patients undergoing distal gastrectomy for gastric cancer. Gastric Cancer. 20(3):496-507, 2017.
12. Minamikawa K, Shibata M*, Gonda K*, Ujiie D*, Ashizawa M*, Nakajima T*, Okayama H*, Sakamoto W*, Saito M*, Momma T*, Mimura K* , Ohki S*, Shimura T, Ohto H, Takenoshita S, Kono K*. IL-17 and VEGF are significantly associated with disease progression involving systemic inflammation in patients with gastric and colorectal cancers. Ann. Cancer Res. Ther. 25(2):67-76, 2017.
13. Mimura K*, Kua LF, Shimasaki N, Shiraishi K, Nakajima S, Siang LK, Shabbir A, So J, Yong WP, Kono K*. Upregulation of thioredoxin-1 in activated human NK cells confers increased tolerance to oxidative stress. Cancer Immunol Immunother. 66(5):605-613, 2017.
14. Mimura K*, Teh JL, Okayama H*, Shiraishi K, Kua LF, Koh V, Smoot DT, Ashktorab H, Oike T, Suzuki Y, Fazreen Z, Asuncion BR, Shabbir A, Yong WP, So J, Soong R, Kono K*. PD-L1 expression is mainly regulated by interferon gamma associated with JAK-STAT pathway in gastric cancer. Cancer Sci. 2018 Jan;109(1):43-53. doi: 10.1111/cas.13424. Epub 2017 Nov 18.
15. Momma T*, Okayama H*, Saitou M*, Sugeno H*, Yoshimoto N*, Takebayashi Y, Ohki S*, Takenoshita S. Expression of circadian clock genes in human colorectal adenoma and carcinoma. Oncol Lett. 14(5):5319-5325, 2017.
16. Ohkouchi C, Kumamoto K, Saito M*, Ishigame T, Suzuki SI, Takenoshita S, Harris CC. ING2, a tumor associated gene, enhances PAI1 and HSPA1A expression with HDAC1 and mSin3A through the PHD domain and C terminal. Mol Med Rep. 16(5):7367-7374, 2017.
17. Onozawa H*, Saito M*, Saito K*, Kanke Y*, Watanabe Y*, Hayase S*, Sakamoto W*, Ishigame T, Momma T*, Ohki S*, Takenoshita S. Annexin A1 is involved in resistance to 5-FU in colon cancer cells. Oncology Rep. 37(1):235-240, 2017.
18. Saito M*, Fujiwara Y, Asao T, Honda T, Shimada Y, Kanai Y, Tsuta K, Kono K*, Watanabe S, Ohe Y, Kohno T. The genomic and epigenomic landscape in thymic carcinoma. Carcinogenesis, 38(11):1084-1091, 2017.
19. Saito M*, Okayama H*, Saito K*, Ando J, Ohki S*, Ishii Y, Takenoshita S. CDX2 is involved in microRNA-related inflammatory carcinogenesis in gastric cancer. Oncol Lett. 14(5):6184-6190, 2017.
20. Sato H, Niimi A, Yasuhara T, Permata TBM, Hagiwara Y, Isono M, Nuryadi E, Sekine R, Oike T, Kakoti S, Yoshimoto Y, Held KD, Suzuki Y, Kono K*, Miyagawa K, Nakano T, Shibata A. DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells. Nat Commun. 8(1):1751, 2017
21. Sato Y, Gonda K*, Harada M, Tanisaka Y, Arai S, Mashimo Y, Iwano H, Sato H, Ryozawa S, Takahashi T, Sakuramoto S, Shibata M*. Increased neutrophil-to-lymphocyte ratio is a novel marker for nutrition, inflammation and chemotherapy outcome in patients with locally advanced and metastatic esophageal squamous cell carcinoma. Biomed Rep. 7(1):79-84, 2017.
22. Shimura T, Shibata M*, Gonda K*, Kofunato Y, Okada R, Ishigame T, Kimura T, Kenjo A, Marubashi S, Kono K*, Takenoshita S. Clinical Significance of Soluble Intercellular Adhesion Molecule-1 and Interleukin-6 in Patients with Extrahepatic Cholangiocarcinoma. J Invest Surg. 19:1-8. 2017.
23. Shimura T, Shibata M*, Gonda K*, Kofunato Y, Okada R, Ishigame T, Kimura T, Kenjo A, Kono K*, Marubashi S. Significance of Circulating Galectin-3 in Patients with Pancreatobiliary Cancer. Anticancer Res. 37(9):4979-4986, 2017.
24. Tachibana K, Saito M*, Imai J, Ito E, Yanagisawa, Honma R, Saito K, Ando J, Momma T*, Ohki S*, Ohtake T, Watanabe S, Waguri S and Takenoshita S. Clinicopathological examination on DPEP1 expression in colorectal cancer. Biomed Rep. 6(4):423-428, 2017.
25. Tachibana K, Shibata M, Gonda K, Matsumoto Y, Nakajima T, Abe N, Ohtake T, Shimura T, Ohto H, Kono K and Takenoshita S. IL-17 and vascular endothelial growth factor (VEGF) are increased and correlated to systemic inflammation, immune suppression and malnutrition in patients with breast cancer. European J of Inflammation, 20: 1-10, 2017
26. Tada T*, Honma R, Imai JI, Saze Z*, Kogure M, Marubashi S, Tasaki K, Unakami M, Ezaki J, Tamura H, Nishikawa A, Hashimoto Y, Waguri S, Watanabe S, Gotoh M. A novel gene expression scoring system for accurate diagnosis of basaloid squamous cell carcinoma of the esophagus. Int J Oncol. 51(3):877-886, 2017.
27. Zhu L, Rossi M, Cui Y, Lee RJ, Sakamoto W*, Perry NA, Urs NM, Caron MG, Gurevich VV, Godlewski G, Kunos G, Chen M, Chen W, Wess J. Hepatic β-arrestin 2 is essential for maintaining euglycemia. J Clin Invest. 127(8):2941-2945, 2017.
28. Zhu L, Almaca J, Dadi PK, Hong H, Sakamoto W*, Rossi M, Lee RJ, Vierra NC, Lu H, Cui Y, McMillin SM, Perry NA, Gurevich VV, Lee A, Kuo B, Leapman RD, Matschinsky FM, Doliba NM, Urs NM, Caron MG, Jacobson DA, Caicedo A, Wess J. β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions. Nat Commun. 8:14295, 2017.
1. 芦澤舞*, 岡山洋和*, Aung Kyi Thar Min*, 野田勝, 青砥慶太*, 中島隆宏*, 石亀輝英, 三村耕作*, 河野浩二*. ミスマッチ修復機構欠損を有する大腸癌におけるmicroRNAによるPD-L1制御機構. 癌と化学療法. 44(10):889-891, 2017.
2. 大木進司*, 加瀬晃志*, 千田峻*, 早瀬傑*, 藤田正太郎*, 門馬智之*, 高和正, 河野 浩二*, 大竹 徹, 竹之下 誠一. 80歳以上の高齢者大腸癌におけるリスク評価と予後の解析. 癌と化学療法. 43(12):1532-1534, 2016.
3. 志村龍男, 柴田昌彦*, 小船戸康英, 石亀輝英, 岡田良, 木村隆, 見城明, 丸橋繁, 大木進司*, 河野浩二*, 竹之下誠一. 肝胆膵癌における血中galectin-3の意義. 日本臨床外科学会雑誌 78巻4号, 633-637, 2017.
②総説等
1. Kono K*, Yong WP, Okayama H*, Shabbir A, Momma T*, Ohki S*, Takenoshita S, So J. Intraperitoneal chemotherapy for gastric cancer with peritoneal disease: experience from Singapore and Japan. Gastric Cancer. 20(Suppl 1):122-127, 2017.
1. 河野浩二*. 胃癌 化学療法. 日本外科学会雑誌. 118巻3号, 351-353, 2017.
2. 柴田昌彦、河野浩二 癌免疫カンファレンスルーム、連載の開始にあたって、消化器外科40(10): 1474-1476,2017
3. 柴田昌彦 癌免疫カンファレンスルーム、癌患者で起きている生体の変化、消化器外科40(11): 1575-1580,2017
4. 三村耕作*、河野浩二*. がんワクチンと免疫チェックポイント阻害剤. 癌と化学療法. 44(9):733-736, 2017.
5. 三村耕作*、中山裕子、中澤匡男、河野浩二*. 腫瘍微小環境の解析から診た抗PD-1/抗PD-L1抗体の適応. 癌と化学療法. 44(11):981-983, 2017.
③症例報告
1. Abe T, Nirei A*, Suzuki N, Todate Y, Azami A, Waragai M, Sato A, Takano Y, Nishino N, Sakuma H, Teranishi Y. Neuroendocrine tumor of the extrahepatic bile duct: A case report. Int J Surg Case Rep. 40:6-9, 2017.
2. Aoto K*, Shimura T, Kofunato Y, Okada R, Yashima R, Kiko Y, Takenoshita S. Acinar Cell Cystadenocarcinoma of the Pancreas. Case Rep Gastroenterol. 11(2):504-510, 2017.
1. 権田憲士*, 立谷陽介, 畠山優一, 柴田昌彦*, 河野浩二*, 六角裕一. 化学療法によりpCR が得られた直腸癌の2 症例. 癌と化学療法. 44(10):944-946, 2017.
2. 権田憲士*, 柴田昌彦*, 安田政実, 立谷陽介, 畠山優一, 河野浩二*, 六角裕一. 長期生存を認めた原発不明癌の3 症例. 癌と化学療法. 44(10):950-952, 2017.
3. 早瀬 傑*, 藤田正太郎*, 石井芳正, 竹之下誠一. 脾原発性悪性リンパ腫の2 治療例. 福島医学会雑誌. 67(2):75-80, 2017.
4. 藤田正太郎*, 大木進司*, 加瀬晃志*, 山内直人*, 千田峻*, 早瀬傑*, 坂本渉*, 門馬智之*, 高和正, 大竹 徹, 河野 浩二*, 竹之下 誠一. 腹腔鏡下幽門側胃切除術後のポートサイト再発を来した高齢者胃癌の1 例. 癌と化学療法. 43(12):1502-1504, 2016.
5. 松井田 元*, 佐瀬 善一郎*, 大須賀 文彦, 遠藤 久仁*, 多田 武志*, 後藤 満一. 腹腔鏡下に切除し得た隆起型蛋白漏出性胃癌の1例. 福島医学雑誌. 67巻2号,81-88, 2017.
6. 渡部 晶之, 佐瀬 善一郎*, 多田 武志*, 花山 寛之*, 佐藤 哲, 遠藤 久仁*, 木村 隆, 大須賀 文彦, 見城 明, 鈴木 剛, 後藤 満一. 外傷性肝外門脈損傷に対して,大伏在静脈グラフトによる門脈再建により救命しえた1例. 日本消化器外科学会雑誌. 50巻3号, 254-261, 2017.
7. 金田 晃尚*, 佐瀬 善一郎*, 多田 武志*, 花山 寛之*, 遠藤 久仁*, 後藤 満一. 食道GISTを併発したc-KIT陽性食道原発悪性黒色腫の1例. 日本臨床外科学会雑誌. 78巻9号 2027-2033, 2017.

(2) 著書・訳書

1. Shibata M, Gonda K, Takenoshita S. Chapter 14, Systemic Inflammation causing multiple clinical symptoms in gastrointestinal cancer. In Gastrointestinal Cancers vol.2 (Kumar AK and Prasad S ed) pp311-323, Nova Science Publishers, New York 2017
1. 大木進司*、佐瀬善一郎*、早瀬 傑*、花山寛之*、多田武志*、河野浩二*. 食道癌切除後胃管再建不能例における有茎空腸再建術. 手術. 71(13): 1789-1792, 2017
2. 齋藤元伸*, 河野隆志. 遺伝子異常に基づく肺腺がんのprecision medicine. 血液内科. 74(1):109-115, 2017.
3. 多田武志*, 佐瀬善一郎*, 花山寛之*, 丸橋繁, 河野浩二*, 後藤満一. 縦隔内限局型特発性食道破裂に対する経腹的胃底部縫着術. 手術. 71巻7号, 1077-1081, 2017.
4. 岡山洋和*、河野浩二*、竹之下誠一(翻訳).  デヴィータがんの分子生物学 第2版 第19章. メディカルサイエンスインターナショナル:2017/6/2

(3) 知的財産権

1. 岡山洋和*、野田勝、河野浩二*. 出願番号:特願2017-170157. 発明の名称:大腸がんの予後バイオマーカー. 2017/09

お問い合わせcontact

ご相談・ご質問などお気軽にお寄せください

公立大学法人福島県立医科大学 消化管外科学講座
〒960-1295 福島県福島市光が丘1
TEL 024-547-1259
MAIL gi-tsurg@fmu.ac.jp